| AnMed Healthcare | NXDN | NEXEDGE 4800 | Anderson | Anderson | 2023-12-19 |
| Ascend Performance Materials | DMR | Motorola Capacity Plus Multi Site (TRBO) | Greenwood | Greenwood | 2017-10-09 |
| Blue Ridge Electric | DMR | Motorola Connect Plus (TRBO) | Various | Multi-County [3] | 2023-11-20 |
| BMW Manufacturing | DMR | Motorola Connect Plus (TRBO) | Greer | Spartanburg | 2016-01-17 |
| BorgWarner Auto Parts | DMR | Conventional Networked | Seneca | Oconee | 2024-03-22 |
| Bowater | Motorola | Type II | Catawba | Multi-County [2] | 2016-12-29 |
| Carribean Resort | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2024-02-04 |
| Catawba Nuclear Plant | DMR | Motorola Capacity Plus Single Site (TRBO) | Rock Hill | York | 2018-06-13 |
| Charleston Wireless Group | Motorola | Type II | Wando | Berkeley | 2014-11-05 |
| Charleston Wireless Group Cap+ | DMR | Motorola Capacity Plus Single Site (TRBO) | Charleston | Charleston | 2024-02-04 |
| Charleston Wireless Group-1 | Motorola | Type I | Walterboro | Colleton | 2010-02-20 |
| Charleston Wireless Group-2 | Motorola | Type I | Ridgeville | Dorchester | 2011-12-26 |
| Charleston Wireless Group/James White | DMR | Motorola Connect Plus (TRBO) | Various | Multi-County [14] | 2024-02-11 |
| Columbia Tower Corp | Motorola | Type II Smartnet | West Columbia | Lexington | 2006-05-15 |
| Crown Reef Resort | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2021-06-06 |
| Dominion Energy Carolina Gas Transmission | DMR | Conventional Networked | Various | Multi-County [4] | 2021-03-14 |
| Duke Energy - Anderson | OpenSky | 9600 baud | Anderson | Anderson | 2011-12-26 |
| Duke Energy - Greenville | OpenSky | 9600 baud | Greenville | Greenville | 2011-08-02 |
| Duke Energy - Greenwood | OpenSky | 9600 baud | Greenwood | Greenwood | 2011-08-02 |
| Duke Energy - Lancaster | OpenSky | 9600 baud | Lancaster | Lancaster | 2011-08-02 |
| Duke Energy - Pickens | OpenSky | 9600 baud | Six Mile | Pickens | 2011-08-02 |
| Duke Energy - Spartanburg | OpenSky | 9600 baud | Spartanburg | Spartanburg | 2011-12-26 |
| Duke Energy - York | OpenSky | 4800 baud | Clover | York | 2016-12-29 |
| Duke Energy P25 | Project 25 | Phase II | Various | Multi-County [116] | 2024-03-03 |
| Duke Energy Progress | Motorola | Type II SmartZone Omnilink | Various | Multi-County [41] | 2022-07-25 |
| Eastman Chemical Company | Motorola | Type II | Columbia | Multi-County [3] | 2013-04-18 |
| Federal Correctional Institution Bennettsville | Motorola | Type II | Bennettsville | Marlboro | 2020-04-12 |
| Federal Correctional Institution Edgefield | Motorola | Type II SmartZone | Edgefield | Edgefield | 2020-04-28 |
| Federal Correctional Institution Estill | Motorola | Type II SmartZone | Estill | Hampton | 2020-04-14 |
| Federal Correctional Institution Williamsburg | Motorola | Type II SmartZone | Salters | Williamsburg | 2017-11-02 |
| FleetTalk Carolinas | NXDN | NEXEDGE 4800 | Various | Multi-County [74] | 2024-04-25 |
| Fujifilm Manufacturing U.S.A. | DMR | Motorola Capacity Plus Single Site (TRBO) | Greenwood | Greenwood | 2017-08-14 |
| Georgia FleetTalk (NXDN) | NXDN | NEXEDGE 4800 | Various | Multi-County [39] | 2024-04-20 |
| Grand Atlantic Ocean Resort | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2021-06-06 |
| Grand Strand Regional Medical Center | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2018-03-26 |
| Greenville Hospital System | DMR | Conventional Networked | Greenville | Greenville | 2023-12-18 |
| Greenville Water System | LTR | Standard | Greenville | Greenville | 2006-05-15 |
| Hampton Inn Myrtle Beach | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2021-06-06 |
| Hilton Grand Vacation | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2019-07-28 |
| Hilton Grand Vacations Ocean Enclave | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2024-02-08 |
| Holiday Inn South Beach | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2021-06-06 |
| Horry County | Project 25 | Phase I | Myrtle Beach | Horry | 2024-04-18 |
| In Touch Systems (Kingstree) | LTR | Standard | Kingstree | Williamsburg | 2011-12-26 |
| In Touch Systems (Sumter) | LTR | Standard | Sumter | Sumter | 2011-12-26 |
| Kimberly Clark | DMR | Motorola Capacity Plus Single Site (TRBO) | Beech Island | Aiken | 2015-06-23 |
| MCA Myrtle Beach Communications (DMR) | DMR | Motorola Connect Plus (TRBO) | Various | Multi-County [4] | 2024-02-08 |
| McCormick County | DMR | Motorola Capacity Plus Multi Site (TRBO) | | McCormick | 2022-09-20 |
| McLeod Regional Medical Center | DMR | Motorola Connect Plus (TRBO) | Florence | Florence | 2022-12-08 |
| Michelin North America Inc | NXDN | NEXEDGE 4800 | Spartanburg | Spartanburg | 2022-03-21 |
| Mid-State Electronics | LTR | Standard | Columbia | Richland | 2011-12-26 |
| Mobile Communications America | DMR | Motorola Connect Plus (TRBO) | Various | Multi-County [8] | 2023-09-20 |
| Mobile Communications America (Bluffton) | Motorola | Type I | Bluffton | Beaufort | 2022-03-04 |
| Montage Palmetto Bluff | DMR | Motorola Capacity Plus Single Site (TRBO) | Bluffton | Beaufort | 2019-06-02 |
| Myrtle Beach Communications (Georgetown) | Motorola | Type IIi Hybrid | Georgetown | Georgetown | 2010-02-19 |
| North Beach Plantation | DMR | Motorola Capacity Plus Single Site (TRBO) | North Myrtle Beach | Horry | 2023-07-30 |
| Nucor Steel Corp | DMR | Motorola Connect Plus (TRBO) | Hugar | Berkeley | 2019-04-27 |
| Nucor Steel Corp. | Motorola | Type IIi Hybrid | Florence | Florence | 2004-06-02 |
| Ocean Lakes Campground | DMR | Motorola Capacity Plus Single Site (TRBO) | Surfside Beach | Horry | 2020-12-11 |
| OceanWatch Villas at Grand Dunes | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2021-06-06 |
| Oconee County Emergency Services | DMR | Conventional Networked | Various | Oconee | 2023-11-20 |
| Orangeburg (City) | LTR | Passport | Orangeburg | Orangeburg | 2011-01-31 |
| Palmetto 800 | Project 25 | Phase II | Various | Statewide | 2024-04-19 |
| Palmetto TRBO/Capital City TRBO | DMR | Motorola Connect Plus (TRBO) | Columbia | Multi-County [5] | 2021-12-31 |
| Ripleys Aquarium | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2022-07-14 |
| Riverbanks Zoo | NXDN | NEXEDGE 4800 | Columbia | Multi-County [2] | 2023-10-05 |
| Savannah River Site | Project 25 | Phase I | Aiken | Multi-County [3] | 2023-07-20 |
| SC HEART DMR Network | DMR | Conventional Networked | Mulitple | Multi-County [21] | 2022-02-15 |
| SC Public Service Authority | Project 25 | Phase II | Various | Multi-County [39] | 2024-02-11 |
| SCANA/SCE and G | DMR | Tier 3 Standard | Various | Multi-County [24] | 2024-02-11 |
| School District of Pickens County | DMR | Motorola Capacity Plus Single Site (TRBO) | Pickens | Pickens | 2022-12-03 |
| Shaw Air Force Base | Project 25 | Phase I | Sumter | Sumter | 2021-02-06 |
| South Carolina Pipeline Corporation | LTR | Standard | Various | Multi-County [2] | 2006-05-15 |
| South Carolina School for the Deaf and Blind | DMR | Motorola Capacity Plus Single Site (TRBO) | Spartanburg | Spartanburg | 2017-02-13 |
| Target Distribution Center 594: Lugoff | LTR | Standard | Lugoff | Kershaw | 2017-01-29 |
| TRBOMAX | DMR | Tier 3 Capacity Max | Various | Multi-County [44] | 2024-02-11 |
| United Parcel Service | DMR | Tier 3 Capacity Max | West Columbia | Lexington | 2022-08-30 |
| United States Air Force (57C) | Project 25 | Phase I | Multiple | Multi-County [19] | 2024-02-29 |
| United States Army (58A) | Project 25 | Phase I | Various | Multi-County [9] | 2024-03-10 |
| United States Marine Corps (00A) | Project 25 | Phase II | Various | Multi-County [7] | 2023-10-30 |
| University of South Carolina | DMR | Motorola Capacity Plus Single Site (TRBO) | Columbia | Richland | 2023-02-23 |
| US Department of Energy: Savannah River Site | Motorola | Type II SmartZone | Aiken | Aiken | 2018-03-08 |
| VC Summer Nuclear Plant | DMR | Motorola Connect Plus (TRBO) | Jenkinsville | Fairfield | 2016-12-24 |
| VC Summer Nuclear Plant | DMR | Motorola Connect Plus (TRBO) | Columbia | Fairfield | 2022-01-05 |
| VoiceLink Communications | Motorola | Type I | Columbia | Richland | 2005-07-28 |
| Wyndham Ocean Blvd | DMR | Motorola Capacity Plus Single Site (TRBO) | Myrtle Beach | Horry | 2017-10-09 |
| Wyndham Plantation Resort | DMR | Motorola Capacity Plus Single Site (TRBO) | | Horry | 2019-07-25 |
| York County SC Public Safety | Project 25 | Phase I | York County | York | 2023-07-10 |
| ZF Transmissions | DMR | Motorola Capacity Plus Single Site (TRBO) | Laurens | Laurens | 2023-06-07 |
